World Ophthalmology Summit - 2018 II World Congress on Drug Discovery and Development - 2018

Dedicated to the soul of Late. "Renato Dulbecco"

Renato Dulbecco (February 22, 1914 – February 19, 2012) was an Italian American, who won the 1975 Nobel Prize in Physiology or Medicine for his work on oncoviruses, which are viruses that can cause cancer when they infect animal cells.

Born in Italy in 1914, Renato Dulbecco was a virologist who won the Nobel Prize for Physiology or Medicine along with Howard M. Temin and David Baltimore. In the 1950s, the three men pioneered the growing of viruses in a culture, lending insight into cell growth. The research helped pave the way for studying cancer cells in the fight against cancer. Dulbecco died in 2012 in La Jolla, California.

In 1965 he received the Marjory Stephenson Prize from the Society for General Microbiology. In 1973 he was awarded the Louisa Gross Horwitz Prize from Columbia University together with Theodore Puck and Harry Eagle. Dulbecco was the recipient of the Selman A. Waksman Award in Microbiology from the National Academy of Sciences in 1974. He was elected a Foreign Member of the Royal Society (ForMemRS) in 1974.

After the war he resumed his work at Levi's laboratory, but soon he moved, together with Levi-Montalcini, to the U.S., where, at Indiana University, he worked with Salvador Luria on bacteriophages. In the summer of 1949 he moved to Caltech, joining Max Delbrück's group (see Phage group). There he started his studies about animal oncoviruses, especially of polyoma family. In the late 1950s, he took Howard Temin as a student, with whom, and together with David Baltimore, he would later share the 1975 Nobel Prize in Physiology or Medicine for "their discoveries concerning the interaction between tumour viruses and the genetic material of the cell." Temin and Baltimore arrived at the discovery of reverse transcriptase simultaneously and independently from each other; although Dulbecco did not take direct part in either of their experiments, he had taught the two methods they used to make the discovery.

Throughout this time he also worked with Marguerite Vogt. In 1962, he moved to the Salk Institute and then in 1972 to The Imperial Cancer Research Fund (now named the Cancer Research UK London Research Institute). In 1986 he was among the scientists who launched the Human Genome Project. From 1993 to 1997 he moved back to Italy, where he was president of the Institute of Biomedical Technologies at C.N.R. (National Council of Research) in Milan. He also retained his position on the faculty of Salk Institute for Biological Studies. Dulbecco was actively involved in research into identification and characterization of mammary gland cancer stem cells until December 2011. His research using a stem cell model system suggested that a single malignant cell with stem cell properties may be sufficient to induce cancer in mice and can generate distinct populations of tumor-initiating cells also with cancer stem cell properties.Dulbecco's examinations into the origin of mammary gland cancer stem cells in solid tumors was a continuation of his early investigations of cancer being a disease of acquired mutations. His interest in cancer stem cells was strongly influenced by evidence that in addition to genomic mutations, epigenetic modification of a cell may contribute to the development or progression of cancer.

In 1975, Dulbecco shared the Nobel Prize in Physiology or Medicine with Howard M. Temin and David Baltimore, for their work in cancer cell transformation. Dulbecco attributed much of his success to the work he did with colleagues such as Giuseppe Levi, Rita Levi-Montalcini, Herman Muller, Max Delbrück and Marguerite Vogt. In his Nobel Prize address, Dulbecco called for increased restrictions on tobacco use and urged governments to make greater efforts to limit the introduction of dangerous chemicals into the environment.

With all great respect, we wish to dedicate this 2nd World Congress on Drug Discovery and Development - 2018 to Late. Renato Dulbecco for his tireless fight against cancer and being the force behind our knowledge of cancer today.

World Ophthalmology Summit - 2018


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World Ophthalmology Summit - 2018

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